Curcuma Domestica en Longa

14 juni 2017

Door: Daniel Wuyts

De wortelstok van beide Zingiberaceae bevat curcumine (= diferuloylmethaan, E100), bijna onoplosbaar in water. Het wordt best opgenomen met peper of vetten zoals het geval is in curry. De combinatie van curcumine met piperidine verhoogt de beschikbaarheid van curcumine 20-voudig, met polysorbaat 9-voudig, met polysorbaat en olie 20-voudig. Fytosomen complexeren curcumine met fosfatidylcholine zodat 450 mg van dit complex zo doeltreffend wordt als 4 g curcumine bij mensen. Onder de vorm van nanodeeltjesemulsies wordt de absorptie van 10[1] tot 27[2] -voudig verhoogd bij de mens. Curcumine wordt nadien snel gecataboliseerd.

Wilt u het hele artikel als PDF ontvangen? Bestel het dan hier voor € 3,50

1. Zhongfa L, Chiu M, Wang J, Chen W, Yen W, Fan-Havard P, et al. Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice. Cancer Chemother Pharmacol. 2012 Mar 4 [cited 2017 May 15];69(3):679–89.
2. Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, et al. Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull. 2011 [cited 2017 May 15];34(5):660–5.
3. Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. [cited 2017 May 15];23(1A):363–98.
4. Wu J-C, Lai C-S, Badmaev V, Nagabhushanam K, Ho C-T, Pan M-H. Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells. Mol Nutr Food Res. 2011 Nov [cited 2017 May 15];55(11):1646–54.
5. Ohashi Y, Tsuchiya Y, Koizumi K, Sakurai H, Saiki I. Prevention of intrahepatic metastasis by curcumin in an orthotopic implantation model. Oncology. 2003 [cited 2017 May 15];65(3):250–8.
6. Di G, Li H, Shen Z, Shao Z. [Analysis of anti-proliferation of curcumin on human breast cancer cells and its mechanism.] Zhonghua Yi Xue Za Zhi. 2003 Oct 25 [cited 2017 May 15];83(20):1764–8.
7. Ray S, Chattopadhyay N, Mitra A, Siddiqi M, Chatterjee A. Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and E-cadherin. J Environ Pathol Toxicol Oncol. 2003 [cited 2017 May 15];22(1):49–58.
8. Chendil D, Ranga RS, Meigooni D, Sathishkumar S, Ahmed MM. Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3. Oncogene. 2004 Feb 26 [cited 2017 May 15];23(8):1599–607.
9. Gao X, Kuo J, Jiang H, Deeb D, Liu Y, Divine G, et al. Immunomodulatory activity of curcumin: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production in vitro. Biochem Pharmacol. 2004 Jul 1 [cited 2017 May 15];68(1):51–61.
10. Foryst-Ludwig A, Neumann M, Schneider-Brachert W, Naumann M. Curcumin blocks NF-kappaB and the motogenic response in Helicobacter pylori-infected epithelial cells. Biochem Biophys Res Commun. 2004 Apr 16 [cited 2017 May 15];316(4):1065–72.
11. Ma TY, Iwamoto GK, Hoa NT, Akotia V, Pedram A, Boivin MA, et al. TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation. Am J Physiol Gastrointest Liver Physiol. 2004 Mar 1 [cited 2017 May 15];286(3):G367-76.
12. Chueh S-CJ, Lai M-K, Liu I-S, Teng F-C, Chen J. Curcumin enhances the immunosuppressive activity of cyclosporine in rat cardiac allografts and in mixed lymphocyte reactions. Transplant Proc. 2003 Jun [cited 2017 May 15];35(4):1603–5.
13. van’t Land B, Blijlevens NMA, Marteijn J, Timal S, Donnelly JP, de Witte TJM, et al. Role of curcumin and the inhibition of NF-kappaB in the onset of chemotherapy-induced mucosal barrier injury. Leukemia. 2004 Feb 11 [cited 2017 May 15];18(2):276–84.
14. Lee J-W, Park S, Kim SY, Um SH, Moon E-Y. Curcumin hampers the antitumor effect of vinblastine via the inhibition of microtubule dynamics and mitochondrial membrane potential in HeLa cervical cancer cells. Phytomedicine. 2016 Jun 15 [cited 2017 May 15];23(7):705–13.